Welcome to Seung Seok Han's lab

Kidney-resident immune cells play a crucial role in maintaining immunological homeostasis. In mice, kidney-resident macrophages make up the majority of resident immune cells and primarily localize to the tubulointerstitial area, where they influence both inflammatory and repair processes following the onset of glomerulitis and tubulitis.

Besides macrophages, various other kidney-resident immune cells are also expected to contribute to kidney homeostasis.​​Our lab actively investigates the homeostatic functions of different kidney-resident immune cell populations. While much of this research has been conducted in mice, it is essential to expand our understanding to humans, as there may be fundamental differences between species. However, information on resident immune cells in human kidneys remains limited.​​​

To address this, we are validating key differences between human and mouse kidney immune cells using human kidney samples. Additionally, we are integrating findings from mouse studies with human omics data to bridge the gap between species. By analyzing the predominant immune cell subsets and their functions in human kidneys, our research aims to deepen the understanding of kidney homeostasis and disease, ultimately providing insights for potential therapeutic interventions.